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AM1248

Item No. 11282

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]tricyclo[3.3.1.13,7]dec-1-yl-methanone
CAS Number
335160-66-2
Molecular Formula
C26H34N2O
Formula Weight
390.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMF:PBS (pH 7.2) (1:4): 0.25 mg/mlDMSO: 10 mg/mlMethanol: 1 mg/ml
λmax
214, 242, 297 nm
SMILES
O=C(C1(C2)C[C@@H]3C[C@H](C1)C[C@H]2C3)C4=CN(CC5N(C)CCCC5)C6=C4C=CC=C6
InChi Code
InChI=1S/C26H34N2O/c1-27-9-5-4-6-21(27)16-28-17-23(22-7-2-3-8-24(22)28)25(29)26-13-18-10-19(14-26)12-20(11-18)15-26/h2-3,7-8,17-21H,4-6,9-16H2,1H3/t18-,19+,20-,21?,26?
InChi Key
JRECAXBHMULNJQ-IYINYKJGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    AM1248 is an adamantoylindole derivative with an N-methylpiperidin-2-ylmethyl substitution at the indole 1-position. It reportedly acts as a moderately potent agonist for both the central CB1 and peripheral CB2 cannabinoid receptors (Kis = 11.9 and 4.8 nM, respectively).1 A related compound, 1-pentyl-3-(1-adamantoyl)indole, along with another synthetic cannabinoid, AM679, was identified as having been sold as a cannabinoid herbal blend known as “smart products” in Hungary in 2011.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Makriyannis, A., and Deng, H. Receptor selective cannabimimetic aminoalkylindoles. 11/620,248, 1-16 (2007).

    2. Jankovics, P., Váradi, A., Tölgyesi, L., et al. Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary. Forensic Sci. Int. 214, 27-32 (2012).