An actin polymerization inhibitor and fungal metabolite
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Isomer(s)
11330Cytochalasin D
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Cytochalasin C

Item No. 11329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,3aR,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione
CAS Number
22144-76-9
Molecular Formula
C30H37NO6
Formula Weight
507.6
Purity
≥99%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: Soluble
SMILES
O[C@H]1[C@H]2[C@@]3([C@@H](/C=C/[C@@](C)(O)C([C@@H](C)C/C=C/2)=O)OC(C)=O)C([C@H](CC4=CC=CC=C4)NC3=O)C(C)=C1C
InChi Code
InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17,22-26,33,36H,10,16H2,1-5H3,(H,31,35)/b13-9+,15-14+/t17-,22-,23-,24?,25?,26+,29+,30+/m0/s1
InChi Key
NAIODHJWOHMDJX-GHFBPWLISA-N
Origin
Fungus/Geniculosporium sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Cytochalasin C is an actin polymerization inhibitor and fungal metabolite that has been found in C. globosum.1,2 It inhibits actin polymerization when used at a concentration of 10 µM.1 Cytochalasin C is cytotoxic to HeLa cells (IC50 = <0.32 µg/ml).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Walling, E.A., Krafft, G.A., and Ware, B.R. Actin assembly activity of cytochalasins and cytochalasin analogs assayed using fluorescence photobleaching recovery. Arch. Biochem. Biophys. 264(1), 321-332 (1988).

    2. Umeda, M., Ohtsubo, K., Saito, M., et al. Cytotoxicity of new cytochalasans from Chaetomium globosum. Experientia 31(4), 435-438 (1975).