An internal standard for the quantification of PGDM
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Unlabeled Version(s)
13454PGDM
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PGDM-d4

Item No. 11344

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,11β-dihydroxy-15-oxo-13,14-dihydro-2,3,18,19-tetranor-prostan-1,20-dioic acid-18,18',19,19'-d4
Synonyms
  • Prostaglandin D Metabolite-d4
Molecular Formula
C16H20D4O7
Formula Weight
332.4
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](CCC(C([2H])([2H])C([2H])([2H])C(O)=O)=O)[C@@H](O)C1
InChi Code
InChI=1S/C16H24O7/c17-10(6-8-16(22)23)5-7-12-11(13(18)9-14(12)19)3-1-2-4-15(20)21/h1-2,11-14,18-19H,3-9H2,(H,20,21)(H,22,23)/b2-1-/t11-,12-,13+,14+/m1/s1/i6D2,8D2
InChi Key
XSGSZQDCVYMZGQ-BNSPUNBTSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

    $195

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    50 µg

    $368

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    100 µg

    $692

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    Product Description

    PGDM-d4 is intended for use as an internal standard for the quantification of PGDM by GC- or LC-MS. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 PGDM is a major urinary metabolite of PGD2 with a unique lower sidechain that readily undergoes reversible cyclization.2 It is used as a biomarker to assess endogenous production of PGD2.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35(2), 277-300 (1988).

    2. Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 193(1), 142-148 (1991).