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Ketazolam

Item No. 11449

Restricted Product (Schedule IV)
Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • NSC 338158
  • U 28774
Technical Information
Formal Name
11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione
CAS Number
27223-35-4
Molecular Formula
C20H17ClN2O3
Formula Weight
368.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlMethanol: 1 mg/ml
SMILES
CN(C(C=CC(Cl)=C1)=C1C(OC(C)=CC2=O)(C3=CC=CC=C3)N2C4)C4=O
InChi Code
InChI=1S/C20H17ClN2O3/c1-13-10-18(24)23-12-19(25)22(2)17-9-8-15(21)11-16(17)20(23,26-13)14-6-4-3-5-7-14/h3-11H,12H2,1-2H3
InChi Key
PWAJCNITSBZRBL-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
IV
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ketazolam is a benzodiazepine derivative that was used as an anxiolytic in the 1980s.1,2 Tolerance within fifteen days, physical dependence, and benzodiazepine withdrawal syndrome are associated with ketazolam use.3 This product is intended for forensic purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rickels, K., Csanalosi, I., Greisman, P., et al. Ketazolam and diazepam in anxiety: A controlled study. J. Clin. Pharmacol. 20(10), 581-589 (1980).

    2. Kim, K.K., Sirman, A., Trainor, F.S., et al. Anxiolytic efficacy and safety of ketazolam compared with diazepam and placebo. Clin. Ther. 3(1), 9-14 (1980).

    3. Higgitt, A., Fonagy, P., and Lader, M. The natural history of tolerance to the benzodiazepines. Psychol. Med. Monogr. Suppl. 13, 1-55 (1988).