An Analytical Reference Standard
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Unlabeled Version(s)
9000767JWH 250 N-(5-hydroxypentyl) metabolite
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JWH 250 N-(5-hydroxypentyl) metabolite-d5

Item No. 11474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[1-(5-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5]-2-(2-methoxyphenyl)-ethanone
CAS Number
2748212-89-5
Molecular Formula
C22H20D5NO3
Formula Weight
356.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A 1 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 14 mg/ml
λmax
212, 245, 303 nm
SMILES
O=C(CC1=C(OC)C=CC=C1)C2=C([2H])N(CCCCCO)C3=C([2H])C([2H])=C([2H])C([2H])=C32
InChi Code
InChI=1S/C22H25NO3/c1-26-22-12-6-3-9-17(22)15-21(25)19-16-23(13-7-2-8-14-24)20-11-5-4-10-18(19)20/h3-6,9-12,16,24H,2,7-8,13-15H2,1H3/i4D,5D,10D,11D,16D
InChi Key
BEAGHVHOGRTTHK-CGSQFYLRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 250 N-(5-hydroxypentyl) metabolite-d5 (Item No. 11474) is intended for use as an internal standard for the quantification of JWH 250 N-(5-hydroxypentyl) metabolite (Item No. 9000767) by GC- or LC-MS. Cannabimimetic indoles, including certain “JWH” compounds, have been identified in herbal blends.1 Hydroxylated and glucuronidated metabolites of two closely-related compounds, JWH 015 and JWH 018, have been identified from in vitro liver microsomal metabolism and from urine, respectively.2,3,4 JWH 250 is a cannabimimetic indole that is structurally- and functionally-related to JWH 015 and JWH 018. JWH 250 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 250 that would be detectable both in serum and in urine.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uchiyama, N., Kikura-Hanajiri, R., Kawahara, N., et al. Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol. 27(2), 61-66 (2009).

    2. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386(5), 1345-1355 (2006).

    3. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).

    4. Moran, C.L., Le, V.H., Chimalakonda, K.C., et al. Quantitative measurement of JWH-018 and JWH-073 metabolites excreted in human urine. Anal. Chem. 83(11), 4228-4236 (2011).