A small molecule survivin suppressant
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Alternative(s)
36827YM-155 (chloride)
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YM-155

Item No. 11490

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,9-dihydro-1-(2-methoxyethyl)2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium, bromide
CAS Number
781661-94-7
Synonyms
  • Sepantronium bromide
Molecular Formula
C20H19N4O3 • Br
Formula Weight
443.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
246, 252, 271, 344 nm
SMILES
O=C(C1=C2N(CCOC)C(C)=[N+]1CC3=CN=CC=N3)C4=CC=CC=C4C2=O.[Br-]
InChi Code
InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
InChi Key
QBIYUDDJPRGKNJ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer. YM-155 is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter.1 It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM.2 At concentrations up to 100 nM, YM-155 has little effect on expression levels of other IAP- or Bcl-2-related proteins.2 YM-155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, N., Yamauchi, T., Hiramoto, M., et al. Interleukin enhancer-binding factor 3/NF110 is a target of YM155, a suppressant of survivin. Mol. Cell. Proteomics 11(7), (2012).

    2. Nakahara, T., Takeuchi, M., Kinoyama, I., et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 67(17), 8014-8021 (2007).

    3. Na, Y.S., Yang, S.J., Kim, S.M., et al. YM155 induces EGFR suppression in pancreatic cancer cells. PLoS One 7(6), (2012).