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ABT-888 (hydrochloride)

Item № 11505
CAS № 912445-05-7
Purity ≥98%
product image
                (CAS 912445-05-7)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $35.00 0.00
     5 mg $88.00 0.00
     10 mg $116.00 0.00
     25 mg $219.00 0.00

Pricing updated 2019-07-18. Prices are subject to change without notice.

Description
Synonyms
  • Veliparib

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis.1,2 ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).3 It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.4,5 ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).3 It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.4,5 ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.6,7

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Technical Information
Formal Name
2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride
CAS Number
912445-05-7
Synonyms
  • Veliparib
Molecular Formula
C13H16N4O • 2HCl
Formula Weight
317.2
Purity
≥98%
Formulation
A crystalline solid
λmax
269, 292 nm
SMILES
NC(C1=CC=CC2=C1N=C([C@@]3(NCCC3)C)N2)=O.Cl.Cl
InChI Code
InChI=1S/C13H16N4O.2ClH/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12;;/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17);2*1H/t13-;;/m1../s1
InChI Key
DSBSVDCHFMEYBX-FFXKMJQXSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

View the Cayman Structure Database for chemical structure definitions for many Cayman products

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References & Product Citations
Product Description References

1. Davar, D., Beumer, J.H., Hamieh, L., et al. Role of PARP inhibitors in cancer biology and therapy Current Medicinal Chemistry 19(23), 3907-3921 (2012).

2. Javle, M., and Curtin, N.J. The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy Ther. Adv. Med. Oncol. 3(6), 257-267 (2011).

3. Donawho, C.K., Luo, Y., Penning, T.D., et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models Clinical Cancer Research 13(9), 2728-2737 (2007).

4. Albert, J.M., Cao, C., Kim, K.W., et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models Clinical Cancer Research 13(10), 3033-3042 (2007).

5. Liu, X., Luo, X., Shi, Y., et al. Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage Cancer Biology and Therapy 7(6), 934-941 (2008).

6. Shelton, J.W., Waxweiler, T.V., Landry, J., et al. In vitro and in vivo enhancement of chemoradiation using the oral PARP inhibitor ABT-888 in colorectal cancer cells Int.J.Radiat.Oncol.Biol.Phys. 86(3), 469-476 (2013).

7. Shunkwiler, L., Ferris, G., and Kunos, C. Inhibition of poly(ADP-ribose) polymerase enhances radiochemosensitivity in cancers proficient in DNA double-strand break repair International Journal of Molecular Sciences 14(2), 3773-3785 (2013).

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