A mixture of PGB1 oligomers with antioxidant and anti-inflammatory activity
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Prostaglandin Bx

Item No. 11510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
39306-29-1
Synonyms
  • PGBx
Molecular Formula
(PGB)n n=3-5
Purity
Mixture of oligomers
Formulation (Request formulation change)
A 5 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: >100 mg/mlDMSO: >100 mg/mlEthanol: >100 mg/mlPBS (pH 7.2): 3.8 mg/ml
λmax
236 nm
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $35

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    1 mg

    $65

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    5 mg

    $258

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    10 mg

    $451

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    Product Description

    Prostaglandin Bx (PGBx) is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Polis, B.D., Polis, E., and Kwong, S. Protection and reactivation of oxidative phosphorylation in mitochondria by a stable free-radical prostaglandin polymer (PGBχ). Proc. Natl. Acad. Sci. USA 76(4), 1598-1602 (1979).

    2. Kumashiro, R., Devlin, T.M., Kholoussy, A.M., et al. Prostaglandin Bχ in the prevention of stress ulcers in rats. Int. Surg. 70, 247-250 (1985).

    3. Franson, R.C., Rosenthal, M.D., and Regelson, W. Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity. Prostaglandins Leukot. Essent. Fatty Acids 43(2), 63-70 (1991).