HMGB1 Monoclonal Antibody (Clone IMG19N15F4)

High Mobility Group Protein B₁ (HMGB1) belongs to the HMGB family and contains two HMG box DNA-binding domains. It is a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, and is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. HMGB1 also act as DNA nuclear binding protein that has been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE).¹ It is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.²

WARNING This product is not for human or veterinary use.

1. Cohen, M.J., Brohi, K., Calfee, C.S., et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: Role of injury severity and tissue hypoperfusion. Crit. Care 13(6), R174 (2009).

2. Yang, H., and Tracey, K.J. Targeting HMGB1 in inflammation. Biochim. Biophys. Acta 1799(1-2), 149-156 (2010).