A negative control for MI-2
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MI-nc (hydrochloride)

Item No. 11621

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-ethyl-4-[4-(1,3,4-thiadiazol-2-yl)-1-piperazinyl]-thieno[2,3-d]pyrimidine, dihydrochloride
CAS Number
1934302-23-4
Molecular Formula
C14H16N6S2 • 2HCl
Formula Weight
405.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 1.3 mg/mlEthanol: 0.1 mg/mlPBS (pH 7.2): 0.16 mg/ml
λmax
223, 285 nm
SMILES
CCC(S1)=CC(C1=NC=N2)=C2N3CCN(C4=NN=CS4)CC3.Cl.Cl
InChi Code
InChI=1S/C14H16N6S2.2ClH/c1-2-10-7-11-12(15-8-16-13(11)22-10)19-3-5-20(6-4-19)14-18-17-9-21-14;;/h7-9H,2-6H2,1H3;2*1H
InChi Key
QFOIGNCIUPMVOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Menin, a product of the multiple endocrine neoplasia gene, is an essential component of histone methyltransferase complexes involving the mixed lineage leukemia (MLL) gene product.1,2 Also, the leukemogenic activity of MLL fusion proteins depends on their direct interaction with menin.3 MI-nc is a weak inhibitor of the menin-MLL fusion protein interaction (IC50 = 193 μM).3 It is intended as a negative control compound for tests involving MI-2 (Item No. 11620), which more potently binds menin, blocks the menin-MLL interaction (IC50 = 0.45 μM), and induces apoptosis in cells expressing MLL fusion proteins.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chandrasekharappa, S.C., Guru, S.C., Manickam, P., et al. Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276(5311), 404-407 (1997).

    2. Guccione, E., Bassi, C., Casadio, F., et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449(7164), 933-937 (2007).

    3. Grembecka, J., He, S., Shi, A., et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat. Chem. Biol. 8(3), 277-284 (2012).