An inhibitor of MAO-B
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Lazabemide

Item No. 11640

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminoethyl)-5-chloro-2-pyridinecarboxamide
CAS Number
103878-84-8
Synonyms
  • Ro 19-6327/000
Molecular Formula
C8H10ClN3O
Formula Weight
199.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Methanol: 2 mg/mlMethanol:PBS (pH7.2) (1:10): 0.1 mg/ml
λmax
230, 274 nm
SMILES
ClC1=CC=C(C(NCCN)=O)N=C1
InChi Code
InChI=1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,(H,11,13)
InChi Key
JZXRLKWWVNUZRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $37

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    10 mg

    $69

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    50 mg

    $280

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    Product Description

    Lazabemide is an inhibitor of monoamine oxidase B (MAO-B; Ki = 0.084 µM).1 It is selective for MAO-B over MAO-A (IC50s = 0.02 and 640 µM, respectively).2 Lazabemide inhibits rat liver MAO-B ex vivo with an ED50 value of 53 nmol/kg.3 It inhibits ischemia-reperfusion injury-induced hydroxyl radical formation in mouse cerebral ventricles when administered at a dose of 3 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cesura, A.M., Gottowik, J., Lahm, H.W., et al. Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur. J. Biochem. 236(3), 996-1002 (1996).

    2. Ozaita, A., Olmos, G., Boronat, M.A., et al. Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liver. Br. J. Pharmacol. 121(5), 901-912 (1997).

    3. Henriot, S., Kuhn, C., Kettler, C., et al. Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: Preclinical and clinical findings. J. Neural Transm. Suppl. 41, 321-325 (1994).

    4. Suzuki, T., Akaike, N., Ueno, K., et al. MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Pharmacology 50(6), 357-362 (1995).