A potent inhibitor of necroptosis
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Product Categories

Product Type

Biochemicals

Research Area

Cell Biology
Cell Death
Necroptosis

Necrostatin-2

Item No. 11657

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5R-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione
CAS Number
852391-19-6
Synonyms
  • Cl-Necrostatin analog
  • Nec-2
Molecular Formula
C13H12ClN3O2
Formula Weight
277.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.50 mg/mlDMSO: 14 mg/mlEthanol: 3 mg/ml
λmax
222, 283 nm
SMILES
O=C([C@H](N1)CC2=CNC3=C(Cl)C=CC=C32)N(C)C1=O
InChi Code
InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1
InChi Key
WIKGAEMMNQTUGL-SNVBAGLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $37

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    5 mg

    $132

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    10 mg

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    Product Description

    Necrostatin-2 is a potent inhibitor of necroptosis with an EC50 of 50 nM in Jurkat T cells deficient of Fas-associated protein with death domain (FADD) and treated with TNF-α.1 It is approximately 4-fold more active than the (S)-enantiomer (EC50 = 230 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Teng, X., Degterev, A., Jagtap, P., et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg. Med. Chem. Lett. 15(22), 5039-5044 (2005).