A 5-LO inhibitor
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11-keto-β-Boswellic Acid

Item No. 11668

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,4β)-3-hydroxy-11-oxo-urs-12-en-23-oic acid
CAS Number
17019-92-0
Synonyms
  • 11-oxo-β-Boswellic acid
  • KBA
Molecular Formula
C30H46O4
Formula Weight
470.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 5 mg/ml
λmax
248 nm
SMILES
O=C1C=C2[C@](CC[C@]3(C)C2[C@@H](C)[C@H](C)CC3)(C)[C@]4(C)CCC5[C@@](C)(C(O)=O)[C@H](O)CC[C@]5(C)C41
InChi Code
InChI=1S/C30H46O4/c1-17-8-11-26(3)14-15-28(5)19(23(26)18(17)2)16-20(31)24-27(4)12-10-22(32)30(7,25(33)34)21(27)9-13-29(24,28)6/h16-18,21-24,32H,8-15H2,1-7H3,(H,33,34)/t17-,18+,21?,22-,23?,24?,26-,27+,28-,29-,30?/m1/s1
InChi Key
YIMHGPSYDOGBPI-BVIVALHHSA-N
Origin
Plant/Boswellia serrata
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

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    10 mg

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    Product Description

    11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).1 Boswellic acids are specific, non-redox inhibitors of leukotriene synthesis via 5-lipoxygenase that demonstrate anti-inflammatory and anti-arthritic actions.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ammon, H.P., Safayhi, H., Mack, T., et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol. 38(2-3), 113-119 (1993).

    2. Safayhi, H., Mack, T., Sabieraj, J., et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146 (1992).

    3. Mostafa, D.M., Ammar, N.M., Basha, M., et al. Transdermal microemulsions of Boswellia carterii Bird: Formulation, characterization and in vivo evaluation of anti-inflammatory activity. Drug Deliv. 22(6), 748-756 (2015).

    4. Wang, Q., Pan, X., Wong, H.H., et al. Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage 22(1), 128-132 (2014).