A withanolide
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Biochemicals
Natural Products

Research Area

Cancer
Immunology & Inflammation

12-Deoxywithastramonolide

Item No. 11669

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6α,7α-epoxy-5α,22R,27-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
CAS Number
60124-17-6
Synonyms
  • Baimantuoluoside C aglycone
  • 27-Hydroxywithanolide B
Molecular Formula
C28H38O6
Formula Weight
470.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
224 nm
SMILES
CC(C1)=C(CO)C(O[C@@]1([H])[C@@H](C)[C@@]2([H])CC[C@@]3([H])[C@]4([H])[C@H]5[C@H](O5)[C@@]([C@@]6(C)[C@@]4([H])CC[C@@]32C)(O)CC=CC6=O)=O
InChi Code
InChI=1S/C28H38O6/c1-14-12-20(33-25(31)16(14)13-29)15(2)17-7-8-18-22-19(9-11-26(17,18)3)27(4)21(30)6-5-10-28(27,32)24-23(22)34-24/h5-6,15,17-20,22-24,29,32H,7-13H2,1-4H3/t15-,17+,18-,19-,20+,22-,23-,24-,26+,27-,28-/m0/s1
InChi Key
AWVMHXZWAKRDGG-MEBIVHGNSA-N
Origin
Plant/Withania somnifera
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $224

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    5 mg

    $838

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    Cayman Chemical
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    Product Description

    12-Deoxywithastramonolide is a withanolide found in W. somnifera roots.1 It has anti-inflammatory activity, reducing Tnf-α and increasing Il-10 production in mice following oral administration at doses ranging from 50-200 mg/kg. 12-Deoxywithastramonolide also reduces the growth of A549 lung and HT-29 colorectal cancer cells (IC50s = 47.1 and 29.8 μM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Srivastava, P., Maurya, U.S., Pal, A., et al. Enrichment of aglycone fractions with immunomodulatory potential: Stability and pharmacokinetic of Withania bioactives. Food Res. Int. 54(1), 867-872 (2013).

    2. Rao, P.C., Begum, S., Jahromi, M.A., et al. Cytotoxicity of withasteroids: Withametelin induces cell cycle arrest at G2/M phase and mitochondria-mediated apoptosis in non-small cell lung cancer A549 cells. Tumour Biol. 37(9), 12579-12587 (2016).