A selective 5-LO inhibitor
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3-acetyl-11-keto-β-Boswellic Acid

Item No. 11672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,4β)-3-(acetyloxy)-11-oxo-urs-12-en-23-oic acid
CAS Number
67416-61-9
Synonyms
  • 3-O-acetyl-11-keto-β-Boswellic acid
  • AKBA
Molecular Formula
C32H48O5
Formula Weight
512.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 5 mg/ml
λmax
208, 249 nm
SMILES
O=C1C=C2[C@](CC[C@]3(C)[C@@]2([H])[C@@H](C)[C@H](C)CC3)(C)[C@]4(C)CC[C@@]5([H])[C@@](C)(C(O)=O)[C@H](OC(C)=O)CC[C@]5(C)[C@]41[H]
InChi Code
InChI=1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32?/m1/s1
InChi Key
HMMGKOVEOFBCAU-HUXDCABZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

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    10 mg

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    Product Description

    3-acetyl-11-keto-β-Boswellic acid is a naturally occurring pentacyclic triterpene isolated from the gum resin exudate from the stem of the tree B. serrata (frankincense).1 It selectively inhibits 5-lipoxygenase (IC50 = 1.5 µM) in an enzyme-directed, nonredox, and noncompetitive manner.2 3-acetyl-11-keto-β-Boswellic acid and other members of the boswellic acid family have been studied for potential use in the control of inflammatory diseases, including arthritis and cancer.3,4,5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ammon, H.P., Safayhi, H., Mack, T., et al. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol. 38(2-3), 113-119 (1993).

    2. Safayhi, H., Mack, T., Sabieraj, J., et al. Boswellic acids: Novel, specific, nonredox inhibitors of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 261(3), 1143-1146 (1992).

    3. Zhao, W., Entschladen, F., Liu, H., et al. Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells. Cancer Detect. Prev. 27(1), 67-75 (2003).

    4. Xia, L., Chen, D., Han, R., et al. Boswellic acid acetate induces apoptosis through caspase-mediated pathways in myeloid leukemia cells. Mol. Cancer Ther. 4(3), 381-388 (2005).

    5. Mostafa, D.M., Ammar, N.M., Basha, M., et al. Transdermal microemulsions of Boswellia carterii Bird: Formulation, characterization and in vivo evaluation of anti-inflammatory activity. Drug Deliv. 22(6), 748-756 (2015).

    6. Wang, Q., Pan, X., Wong, H.H., et al. Oral and topical boswellic acid attenuates mouse osteoarthritis. Osteoarthritis Cartilage 22(1), 128-132 (2014).