A fluorogenic elastase substrate
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(Z-Ala-Ala-Ala-Ala)2Rh110

Item No. 11675

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-(3-oxospiro[isobenzofuran-1(3H),9′-[9H]xanthene]-3′,6′-diyl)bis[N-[(phenylmethoxy)carbonyl]-L-alanyl-L-alanyl-L-alanyl-L-alaninamide
CAS Number
149695-85-2
Synonyms
  • (Z-Ala-Ala-Ala-Ala)2Rhodamine110
  • bis-(CBZ-L-alanyl-L-arginine amide) Rhodamine 110
Molecular Formula
C60H66N10O15
Formula Weight
1167.2
Purity
≥95%
Emission
525 nm
Excitation
485 nm
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 2 mg/ml
λmax
229, 234, 285 nm
SMILES
O=C(NC1=CC(OC2=C3C=CC(NC([C@H](C)NC([C@H](C)NC([C@H](C)NC([C@H](C)NC(OCC4=CC=CC=C4)=O)=O)=O)=O)=O)=C2)=C(C35OC(C6=C5C=CC=C6)=O)C=C1)[C@H](C)NC([C@H](C)NC([C@H](C)NC([C@H](C)NC(OCC7=CC=CC=C7)=O)=O)=O)=O
InChi Code
InChI=1S/C60H66N10O15/c1-31(61-49(71)33(3)63-53(75)37(7)67-58(80)82-29-39-17-11-9-12-18-39)51(73)65-35(5)55(77)69-41-23-25-45-47(27-41)84-48-28-42(24-26-46(48)60(45)44-22-16-15-21-43(44)57(79)85-60)70-56(78)36(6)66-52(74)32(2)62-50(72)34(4)64-54(76)38(8)68-59(81)83-30-40-19-13-10-14-20-40/h9-28,31-38H,29-30H2,1-8H3,(H,61,71)(H,62,72)(H,63,75)(H,64,76)(H,65,73)(H,66,74)(H,67,80)(H,68,81)(H,69,77)(H,70,78)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
InChi Key
JGBISHWUFSPAPR-QSVFAHTRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $48

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    5 mg

    $213

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    10 mg

    $355

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    Product Description

    (Z-Ala-Ala-Ala-Ala)2Rh110 is a sensitive fluorogenic elastase substrate.1 The colorless and nonfluorescent (Z-Ala-Ala-Ala-Ala)2Rh110 is selectively cleaved by elastase to yield the highly fluorescent compound rhodamine 110, which can be analyzed with an excitation wavelength of 485 nm and emission wavelength of 525 nm.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, A.F., Struthers, M.D., Pierson, K.B., et al. Nonisotopic DNA detection system employing elastase and a fluorogenic rhodamine substrate. Anal. Chem. 65(17), 2352-2359 (1993).