Aloe-emodin

Aloe-emodin is a hydroxyanthraquinone found in Aloe vera leaves that has potent laxative action by inducing chloride secretion in colonic mucosa and releasing acetylcholine, which stimulates contraction of intestinal smooth muscle.¹ It also demonstrates anti-tumor activity (ED₅₀s = 1-13 µM), inducing apoptosis in various cancer cells by increasing the production of reactive oxygen species.^2,3 Aloe-emodin is reported to have estrogenic activity as a phytoestrogen and has been shown to inhibit breast cancer cell proliferation by downregulating ERα protein levels, and thus, suppressing transcriptional activation of the receptor.^4,5

WARNING This product is not for human or veterinary use.

1. Xu, J.D., Liu, S., Wang, W., et al. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br. J. Pharmacol. 165(1), 197-207 (2012).

2. Xie, M.J., Ma, Y.H., Miao, L., et al. Emodin-provoked oxidative stress induces apoptosis in human colon cancer HCT116 cells through a p53-mitochondrial apoptotic pathway. Asian Pac. J. Cancer Prev. 15(13), 5201-5205 (2014).

3. Pecere, T., Gazzola, M.V., Mucignat, C., et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 60(11), 2800-2804 (2000).

4. Matsuda, H., Shimoda, H., Morikawa, T., et al. Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): Structure-requirement of hydroxyanthraquinones for estrogenic activity. Bioorg. Med. Chem. Lett. 11(14), 1839-1842 (2001).

5. Huang, P.H., Huang, C.Y., Chen, M.C., et al. Emodin and aloe-emodin suppress breast cancer cell proliferation through ERα inhibition. Evid. Based Complement. Alternat. Med. 2013, 1-12 (2013).