A natural neuroprotectant
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β-Asarone

Item No. 11682

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,4-trimethoxy-5-(1Z)-1-propen-1-yl-benzene
CAS Number
5273-86-9
Synonyms
  • cis-Asarone
Molecular Formula
C12H16O3
Formula Weight
208.3
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 50 mg/ml
λmax
209, 253, 303 nm
SMILES
COC1=CC(/C=C\C)=C(OC)C=C1OC
InChi Code
InChI=1S/C12H16O3/c1-5-6-9-7-11(14-3)12(15-4)8-10(9)13-2/h5-8H,1-4H3/b6-5-
InChi Key
RKFAZBXYICVSKP-WAYWQWQTSA-N
Origin
Plant/Acorus tatarinowii Schott
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $63

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    50 mg

    $268

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    100 mg

    $469

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    Product Description

    β-Asarone is noted for its neuroprotective effects, as it ameliorates depression, reduces dopamine-induced neurotoxicity, and attenuates damage in a model of stroke.1,2,3 In isolated neurons and in brains, β-asarone blocks autophagy, reduces inflammation, and inhibits apoptosis.2,3,4 While β-asarone inhibits apoptosis in neurons, it induces apoptosis in colon cancer cells.5 It also has antimicrobial effects.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, Y.R., Wang, X.Y., Li, S.S., et al. β-Asarone from Acorus gramineus alleviates depression by modulating MKP-1. Genet. Mol. Res. 14(2), 4495-4504 (2015).

    2. Zhang, S., Gui, X.-H., Huang, L.-P., et al. Neuroprotective effects of β-asarone against 6-hydroxy dopamine-induced parkinsonism via JNK/Bcl-2/Beclin-1 Pathway. Mol. Neurobiol. 53(1), 83-94 (2014).

    3. Yang, Y.X., Chen, Y.T., Zhou, X.J., et al. Beta-asarone, a major component of Acorus tatarinowii Schott, attenuates focal cerebral ischemia induced by middle cerebral artery occlusion in rats. BMC Complement. Altern. Med. 13, (2013).

    4. Wei, G., Chen, Y.B., Chen, D.F., et al. β-Asarone inhibits neuronal apoptosis via the CaMKII/CREB/Bcl-2 signaling pathway in an in vitro model and AβPP/PS1 mice. J. Alzheimers Dis. 33(3), 863-880 (2013).

    5. Zou, X., Liu, S.L., Zhou, J.Y., et al. β-Asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. Asian Pac. J. Cancer Prev. 13(10), 5291-5298 (2012).

    6. Rajput, S.B., and Karuppayil, S.M. β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans. Phytomedicine 20(2), 139-142 (2013).