A furanocoumarin with antibacterial activities
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Angelicin

Item No. 11683

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2H-furo[2,3-h]-1-benzopyran-2-one
CAS Number
523-50-2
Synonyms
  • Bakuchicin
  • NSC 404563
Molecular Formula
C11H6O3
Formula Weight
186.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
247, 299 nm
SMILES
O=C1C=CC2=C(C(C=CO3)=C3C=C2)O1
InChi Code
InChI=1S/C11H6O3/c12-10-4-2-7-1-3-9-8(5-6-13-9)11(7)14-10/h1-6H
InChi Key
XDROKJSWHURZGO-UHFFFAOYSA-N
Origin
Plant/Psoralea corylifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $108

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    10 mg

    $173

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    25 mg

    $395

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    Product Description

    Angelicin is a furanocoumarin typically isolated from the seeds of P. corylifolia. Like other furanocoumarins, angelicin has antibacterial activities against a number of Gram (+) and Gram (−) bacteria.1 It has also been shown to prevent tacrine-induced cytotoxicity in human liver-derived HepG2 cells (EC50 = 47 μg/ml) and vascular relaxation in phenylephrine-precontracted rat aorta.2,3 Angelicin also weakly inhibits topoisomerase II (IC50 = 404 μM).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Khatune, N.A., Islam, M.E., Haque, M.E., et al. Antibacterial compounds from the seeds of Psoralea corylifolia. Fitoterapia 75(2), 228-230 (2004).

    2. Cho, H., Jun, J.Y., Song, E.K., et al. Bakuchiol: A hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells. Planta Med. 67(8), 750-751 (2001).

    3. Li, X., Lee, Y.J., Kim, Y.C., et al. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling. Phytother. Res. 25(10), 1574-1578 (2011).

    4. Sun, N.J., Woo, S.H., Cassady, J.M., et al. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod. 61(3), 362-366 (1998).