A natural meroterpene with retinol-like effects
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Bakuchiol

Item No. 11684

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-phenol
CAS Number
10309-37-2
Synonyms
  • (S)-(+)-Bakuchiol
Molecular Formula
C18H24O
Formula Weight
256.4
Purity
≥95%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:2): 0.25 mg/ml
λmax
207, 263 nm
SMILES
OC1=CC=C(/C=C/[C@](C)(C=C)CC/C=C(C)\C)C=C1
InChi Code
InChI=1S/C18H24O/c1-5-18(4,13-6-7-15(2)3)14-12-16-8-10-17(19)11-9-16/h5,7-12,14,19H,1,6,13H2,2-4H3/b14-12+/t18-/m1/s1
InChi Key
LFYJSSARVMHQJB-QIXNEVBVSA-N
Origin
Plant/Psoralea corylifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $59

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    10 mg

    $108

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    25 mg

    $244

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    50 mg

    $456

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    Product Description

    Bakuchiol is a natural meroterpene isolated from P. corylifolia, a plant used in traditional Asian medicine. In addition to having antioxidant and antibacterial actions, bakuchiol has retinol-like effects on gene expression and properties of the skin.1,2,3 Bakuchiol also inhibits DNA polymerase and UDP-glucuronosyltransferase 2B7 (IC50 = 41 µM).4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Katsura, H., Tsukiyama, R.I., Suzuki, A., et al. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob. Agents Chemother. 45(11), 3009-3013 (2001).

    2. Adhikari, S., Indira Priyadarsini, K., and Mukherjee, T. Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants. J. Clin. Biochem. Nutr. 40(3), 174-183 (2007).

    3. Chaudhuri, R.K., and Bojanowski, K. Bakuchiol: A retinol-like functional compound revealed by gene expression profiling and clinically proven to have anti-aging effects. Int. J. Cosmet. Sci. 36(3), 221-230 (2014).

    4. Sun, N.J., Woo, S.H., Cassady, J.M., et al. DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia. J. Nat. Prod. 61(3), 362-366 (1998).

    5. Xu, Y., Li, P., Zhang, X., et al. In vitro evidence for bakuchiol’s influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr. Health Sci. 14(3), 564-569 (2014).