A diterpene with diverse biological activities
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Deacetylforskolin

Item No. 11701

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyldodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
CAS Number
64657-20-1
Synonyms
  • 7-Deactylcoleonol
  • Forskolin D
Molecular Formula
C20H32O6
Formula Weight
368.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleChloroform: Slightly SolubleMethanol: slightly solubleMethanol: Slightly Soluble
SMILES
O=C1C[C@](C)(C=C)O[C@]2(C)[C@@H](O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@]3(C)[C@]21O
InChi Code
InChI=1S/C20H32O6/c1-7-17(4)10-12(22)20(25)18(5)11(21)8-9-16(2,3)14(18)13(23)15(24)19(20,6)26-17/h7,11,13-15,21,23-25H,1,8-10H2,2-6H3/t11-,13-,14-,15-,17-,18-,19+,20-/m0/s1
InChi Key
WPDITXOBNLYZHH-KAACEJSMSA-N
Origin
Plant/Coleus forskohlii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $55

    Add

    5 mg

    $215

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Deacetylforskolin is a diterpene and a derivative of forskolin (Item No. 11018) that has been found in C. forskohlii and has diverse biological activities.1,2,3,4 It activates rat adipocyte adenylyl cyclase (IC50 = 20 µM) and inhibits glucose transport in rat adipocyte plasma membranes.2 Deactylforskolin (30-1,000 µg/kg) reduces blood pressure in spontaneously hypertensive rats.3 It also attenuates hypercapnia-induced impairments in the passive avoidance response in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gabetta, B., Zini, G., and Danieli, B. Minor Diterpenoids of Coleus forskohlii. Phytochemistry 28(3), 859-862 (1989).

    2. Joost, H.G., Habberfield, A.D., Simpson, I.A., et al. Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action. Mol. Pharmacol. 33(4), 449-453 (1988).

    3. Bhat, S.V., Dohadwalla, A.N., Bajwa, B.S., et al. The antihypertensive and positive inotropic diterpene forskolin: Effects of structural modifications on its activity. J. Med. Chem. 26(4), 486-492 (1983).

    4. McCulloch, A.J., Thomson, T.A., and Deacon, R. Hypoxic amnesia and its reversal with forskolin. Biochem. Soc. Trans. 17(1), 212-213 (1988).