6-Gingerol

6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Item No. 92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC₅₀ = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC₅₀ = 10.4 µM).¹ 6-Gingerol also non-competitively inhibits serotonin currents (IC₅₀ = 30.3 µM) and weakly inhibits the cyclooxygenases COX-1 and COX-2 (IC₅₀s = 129 and 125 µM).^2,3

WARNING This product is not for human or veterinary use.

1. Morera, E., De Petrocellis, L., Morera, L., et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg. Med. Chem. Lett. 22(4), 1674-1677 (2012).

2. Jin, Z., Lee, G., Kim, S., et al. Ginger and its pungent constituents non-competitively inhibit serotonin currents on visceral afferent neurons. Korean J. Physiol. Pharmacol. 18(2), 149-153 (2014).

3. Nishio, K., Fukuhara, A., Omata, Y., et al. Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Bioorg. Med. Chem. 16(24), 10332-10337 (2008).

Pázmándi, K., Ágics, B., Szöllősi, A.G., et al. Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells. Eur. J. Pharmacol. 967, 176399 (2024).