A triterpene with anticancer activity
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β-Elemonic Acid

Item No. 11712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-oxo-(13α,14β,17α,20S)-lanosta-8,24-dien-21-oic acid
CAS Number
28282-25-9
Synonyms
  • Elemadienonic Acid
  • 3-Oxotirucallenoic Acid
  • 3-oxo Tirucallic Acid
Molecular Formula
C30H46O3
Formula Weight
454.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
SMILES
C/C(C)=C/CC[C@H](C(O)=O)[C@]1([H])CC[C@]([C@@]1(C)CC2)(C)C3=C2[C@]4(C)[C@](CC3)([H])C(C)(C)C(CC4)=O
InChi Code
InChI=1S/C30H46O3/c1-19(2)9-8-10-20(26(32)33)21-13-17-30(7)23-11-12-24-27(3,4)25(31)15-16-28(24,5)22(23)14-18-29(21,30)6/h9,20-21,24H,8,10-18H2,1-7H3,(H,32,33)/t20-,21-,24-,28+,29-,30+/m0/s1
InChi Key
XLPAINGDLCDYQV-SDTWUMECSA-N
Origin
Plant/Boswellia serrata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity.1,2 It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro.2 β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Atta-ur-Rahman, Naz, H., Fadimatou, et al. Bioactive constituents from Boswellia papyrifera. The Journal of Biological Chemisty 68(2), 189-193 (2005).

    2. Wu, T.-T., Lu, C.L., Lin, H.I., et al. β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion. Oncol. Rep. 35(1), 227-234 (2016).