A telomerase activator
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Cycloastragenol

Item No. 11722

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20,24R-epoxy-9,19-cyclolanostane-3β,6α,16β,25-tetrol
CAS Number
84605-18-5
Synonyms
  • Astramembrangenin
  • Cyclogalegigenin
Molecular Formula
C30H50O5
Formula Weight
490.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:8): 0.25 mg/mlDMSO: 3 mg/mlEthanol: 10 mg/ml
SMILES
CC1(C)[C@@H](O)CC[C@@]2(C3)[C@@]1([H])[C@@H](O)C[C@]4([H])[C@@]23CC[C@@]5(C)[C@@]4(C)C[C@H](O)[C@]5([H])[C@@]6(C)O[C@@H](C(C)(C)O)CC6
InChi Code
InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22-,23-,26+,27-,28-,29-,30+/m0/s1
InChi Key
WENNXORDXYGDTP-ODAITAILSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Cycloastragenol, the aglycone derivative of astragaloside A (Item No. 16677), can be found in various species of Astragalus and is reported to activate telomerase.1 It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, J., Lee, S., Ho, M.K.C., et al. In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator. Drug Metab. Pharmacokinet. 25(5), 477-486 (2010).

    2. Fauce, S.R., Jamieson, B.D., Chin, A.C., et al. Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J. Immunol. 181(10), 7400-7406 (2008).