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2C-B (hydrochloride)

Item No. 11734

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-Bromo-2,5-dimethoxyphenethylamine
Technical Information
Formal Name
4-bromo-2,5-dimethoxy-benzeneethanamine, monohydrochloride
CAS Number
56281-37-9
Molecular Formula
C10H14BrNO2 • HCl
Formula Weight
296.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 2.5 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
296 nm
SMILES
BrC1=C(OC)C=C(CCN)C(OC)=C1.Cl
InChi Code
InChI=1S/C10H14BrNO2.ClH/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12;/h5-6H,3-4,12H2,1-2H3;1H
InChi Key
UJTWHDAMHSIRDK-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    A series of 2,5-dimethoxyphenethylamines, collectively referred to as 2Cs, have psychoactive effects.1,2 The most effective 2C compounds are substituted at the 4 position of the aromatic ring; many are scheduled as illegal substances.3,4 2C-B is described formally as 4-bromo-2,5-dimethoxy phenethylamine. This hallucinogenic designer drug activates the serotonin receptor 5-HT2C (pEC50 = 6.8 for arachidonic acid release).2 Its metabolism has been reviewed.3 LC-MS/MS screening methods for identifying this compound in serum have been developed.5 2C-B is regulated as a Schedule I compound in the United States. This product is intended for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruno, R., Matthews, A.J., Dunn, M., et al. Emerging psychoactive substance use among regular ecstasy users in Australia. Drug Alcohol Depend. 124(1-2), 19-25 (2012).

    2. Moya, P.R., Berg, K.A., Gutiérrez-Hernandez, M.A., et al. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J. Pharmacol. Exp. Ther. 321(3), 1054-1061 (2007).

    3. Meyer, M.R., and Maurer, H.H. Metabolism of designer drugs of abuse: An updated review. Curr. Drug Metab. 11(5), 468-482 (2010).

    4. Nagai, F., Nonaka, R., and Satoh Hisashi Kamimura, K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur. J. Pharmacol. 559(2-3), 132-137 (2007).

    5. Wohlfarth, A., Weinmann, W., and Dresen, S. LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum. Anal. Bioanal. Chem. 396(7), 2403-2414 (2010).

    Product Citations

    Halberstadt, A.L., Chatha, M., Stratford, A., et al. Comparison of the behavioral responses induced by phenylalkylamine hallucinogens and their tetrahydrobenzodifuran (“FLY”) and benzodifuran (“DragonFLY”) analogs. Neuropharmacology 144, 368-376 (2019).