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2C-C (hydrochloride)

Item No. 11735

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 2,5-Dimethoxy-4-chlorophenethylamine
Technical Information
Formal Name
4-chloro-2,5-dimethoxy-benzeneethanamine, monohydrochloride
CAS Number
88441-15-0
Molecular Formula
C10H14ClNO2 • HCl
Formula Weight
252.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 5 mg/mlEthanol: 0.5 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
204, 225, 295 nm
SMILES
NCCC1=CC(OC)=C(Cl)C=C1OC.Cl
InChi Code
InChI=1S/C10H14ClNO2.ClH/c1-13-9-6-8(11)10(14-2)5-7(9)3-4-12;/h5-6H,3-4,12H2,1-2H3;1H
InChi Key
BKHKVQPFRTVWJY-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    A series of 2,5-dimethoxy phenethylamines, collectively referred to as 2Cs, have psychoactive effects.1,2 The most effective 2C compounds are substituted at the 4 position of the aromatic ring. Many are scheduled as illegal substances.3,4 2C-C is described formally as 2,5-dimethoxy-4-chlorophenethylamine. A known hallucinogen, this compound stimulates monoamine receptor activity and inhibits the re-uptake of serotonin and norepinephrine in rat brain synaptosomes (IC50s = 31 and 63 μM, respectively).4,5 LC-MS/MS screening methods for this designer drug have been developed.6 This product is intended for forensic and research purposes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bruno, R., Matthews, A.J., Dunn, M., et al. Emerging psychoactive substance use among regular ecstasy users in Australia. Drug Alcohol Depend. 124(1-2), 19-25 (2012).

    2. Moya, P.R., Berg, K.A., Gutiérrez-Hernandez, M.A., et al. Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors. J. Pharmacol. Exp. Ther. 321(3), 1054-1061 (2007).

    3. Meyer, M.R., and Maurer, H.H. Metabolism of designer drugs of abuse: An updated review. Curr. Drug Metab. 11(5), 468-482 (2010).

    4. Nagai, F., Nonaka, R., and Satoh Hisashi Kamimura, K. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur. J. Pharmacol. 559(2-3), 132-137 (2007).

    5. Nonaka, R., Nagai, F., Ogata, A., et al. In vitro screening of psychoactive drugs by [35S]GTPγS binding in rat brain membranes. Biol. Pharm. Bull. 30(12), 2328-2333 (2007).

    6. Wohlfarth, A., Weinmann, W., and Dresen, S. LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum. Anal. Bioanal. Chem. 396(7), 2403-2414 (2010).