An ecdysteroid that acts as a molting hormone
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Makisterone A

Item No. 11739

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,5β,22R,24R)-2,3,14,20,22,25-hexahydroxy-ergost-7-en-6-one
CAS Number
20137-14-8
Molecular Formula
C28H46O7
Formula Weight
494.7
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CC(O)(C)[C@H](C)C[C@@H](O)[C@](C)(O)[C@@]1([H])CC[C@@]2(O)C3=CC([C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@@]21C)=O
InChi Code
InChI=1S/C28H46O7/c1-15(24(2,3)33)11-23(32)27(6,34)22-8-10-28(35)17-12-19(29)18-13-20(30)21(31)14-25(18,4)16(17)7-9-26(22,28)5/h12,15-16,18,20-23,30-35H,7-11,13-14H2,1-6H3/t15-,16+,18+,20-,21+,22+,23-,25-,26-,27-,28-/m1/s1
InChi Key
IJRBORPEVKCEQD-JMQWOFAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 µg

    $43

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    1 mg

    $112

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    5 mg

    $429

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    Product Description

    Makisterone A is an ecdysteroid that drives molting in insects.1,2 It binds the heterodimeric ecdysone receptor with nanomolar affinity.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cottam, D.M., and Milner, M.J. The effects of several ecdysteroids and ecdysteroid agonists on two Drosophila imaginal disc cell lines. Cell. Mol. Life Sci. 53(7), 600-603 (1997).

    2. Lavrynenko, O., Rodenfels, J., Caravalho, M., et al. The ecdysteroidome of Drosophila: Influence of diet and development. Development 142(21), 3758-3768 (2015).

    3. Tohidi-Esfahani, D., Graham, L.D., Hannan, G.N., et al. An ecdysone receptor from the pentatomomorphan, Nezara viridula, shows similar affinities for moulting hormones makisterone A and 20-hydroxyecdysone. Insect Biochem. Mol. Biol. 41(2), 77-89 (2011).