Ethyl p-methoxycinnamate

Ethyl p-methoxycinnamate (EPMC) is a cinnamic acid ester that has been found in K. galanga and has diverse biological activities.^1,2,3 It is active against T. rubrum, A. niger, S. cerevisiae, and E. floccosum when used at concentrations less than 10 μg/ml.¹ EPMC inhibits COX-1 and COX-2 in vitro (IC₅₀s = 1.12 and 0.83 μM, respectively).² It inhibits microvessel sprouting in isolated rat aortic rings (IC₅₀ = 91.9 µg/ml).⁴ In vivo, EPMC (60 mg/kg) reduces IL-1 and TNF-α production and inhibits granuloma formation in a rat model of cotton pellet-induced granuloma formation. It also increases the latency to tail withdrawal in a hot plate test in rats when administered at doses ranging from 200 to 800 mg/kg.

WARNING This product is not for human or veterinary use.

1. Gupta, S.K., Banerjee, A.B., and Achari, B. Isolation of ethyl p-methoxycinnamate, the major antifungal principle of Curcumba zedoaria. Lloydia 39(4), 218-222 (1976).

2. Umar, M.I., Asmawi, M.Z., Sadikun, A., et al. Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts. Molecules 17(7), 8720-8734 (2012).

3. Umar, M.I., Asmawi, M.Z., Sadikun, A., et al. Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin-1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. Clinics (Sao Paulo) 69(2), 134-144 (2014).

4. Georgopoulou, K., Smirlis, D., Bisti, S., et al. In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes. Planta Med. 73(10), 1081-1088 (2007).