A hepatoprotective plant lignan
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Phyllanthin

Item No. 11745

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1’-[(2S,3S)-2,3-bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxy-benzene
CAS Number
10351-88-9
Synonyms
  • NSC 619043
Molecular Formula
C24H34O6
Formula Weight
418.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
230, 280 nm
SMILES
COC1=C(OC)C=C(C[C@]([C@@](CC2=CC=C(OC)C(OC)=C2)([H])COC)([H])COC)C=C1
InChi Code
InChI=1S/C24H34O6/c1-25-15-19(11-17-7-9-21(27-3)23(13-17)29-5)20(16-26-2)12-18-8-10-22(28-4)24(14-18)30-6/h7-10,13-14,19-20H,11-12,15-16H2,1-6H3/t19-,20-/m1/s1
InChi Key
KFLQGJQSLUYUBF-WOJBJXKFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $36

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    1 mg

    $55

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    5 mg

    $236

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    10 mg

    $402

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    Cayman Chemical
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    Product Description

    Phyllanthin is a major bioactive lignan component of P. amarus with antioxidative and hepatoprotective properties. It scavenges DPPH radicals with an IC50 value of 7.4 µM and, at 30 µM, has been shown to alleviate carbon tetrachloride-induced lipid peroxidation and cytotoxicity in a human hepatoma HepG2 cell line.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krithika, R., Mohankumar, R., Verma, R.J., et al. Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line. Chem. Biol. Interact. 181(3), 351-358 (2009).