An Analytical Reference Standard
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Unlabeled Version(s)
10939JWH 250 N-(4-hydroxypentyl) metabolite
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JWH 250 N-(4-hydroxypentyl) metabolite-d5

Item No. 11749

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(1-(4-hydroxypentyl)-1H-indol-3-yl-2,4,5,6,7-d5)-2-(2-methoxyethanone
CAS Number
1782062-60-5
Molecular Formula
C22H20D5NO3
Formula Weight
356.5
Purity
≥99% deuterated forms (d1-d5)
Formulation
A solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 14 mg/ml
λmax
212, 246, 304 nm
SMILES
CC(O)CCCN1C2=C([2H])C([2H])=C([2H])C([2H])=C2C(C(CC3=C(OC)C=CC=C3)=O)=C1[2H]
InChi Code
InChI=1S/C22H25NO3/c1-16(24)8-7-13-23-15-19(18-10-4-5-11-20(18)23)21(25)14-17-9-3-6-12-22(17)26-2/h3-6,9-12,15-16,24H,7-8,13-14H2,1-2H3/i4D,5D,10D,11D,15D
InChi Key
GMXLLEJMDHWZNM-RNRKPZPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 250 N-(4-hydroxypentyl) metabolite-d5 is intended for use as an internal standard for the quantification of JWH 250 N-(4-hydroxypentyl) metabolite (Item No. 10939) by GC- or LC-mass spectrometry. JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB1 and CB2 receptors (Ki = 11 and 33 nM, respectively).1 It has been identified in herbal blends.2 JWH 250 N-(4-hydroxypentyl) metabolite (Item No. 10939) is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huffman, J.W., Szklennik, P.V., Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 15(18), 4110-4113 (2005).

    2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).

    3. Wintermeyer, A., Möller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018. Anal. Bioanal. Chem. 398(5), 2141-2153 (2010).

    4. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386(5), 1345-1355 (2006).

    5. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).