A photoactive probe to study DNA
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Product Categories

Product Type

Biochemicals
Labeling & Detection
Reactive Probes

Research Area

Psoralen

Item No. 11751

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7H-furo[3,2-g][1]benzopyran-7-one
CAS Number
66-97-7
Synonyms
  • Ficusin
  • Furocoumarin
  • NSC 404562
Molecular Formula
C11H6O3
Formula Weight
186.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
246,290,331, nm
SMILES
O=C1C=CC2=CC3=C(OC=C3)C=C2O1
InChi Code
InChI=1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H
InChi Key
ZCCUUQDIBDJBTK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 mg

    $75

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    25 mg

    $130

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    50 mg

    $241

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    100 mg

    $369

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    Product Description

    Psoralen is a photoactive probe that has been used to investigate nucleic acid structure and function.1 It intercalates into DNA and, when activated by ultraviolet radiation, can create covalent interstrand crosslinks, inducing apoptosis.2 Because of its high UV absorbance, psoralen has been combined with UVA light (PUVA therapy) for the treatment of skin problems such as psoriasis.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Litovchick, A., Clark, M.A., and Keefe, A.D. Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags. Artif. DNA PNA XNA 5(1), (2014).

    2. Vasquez, K.M. Targeting and processing of site-specific DNA interstrand crosslinks. Environ. Mol. Mutagen 51(6), 527-539 (2010).

    3. Ahmed Asim, S., Ahmed, S., and Us-Sehar, N. Psoralen-ultraviolet A treatment with Psoralen-ultraviolet B therapy in the treatment of psoriasis. Pak. J. Med. Sci. 29(3), 758-761 (2013).