A natural compound with immunomodulatory activities
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(+)-ar-Turmerone

Item No. 11759

Technical Information
Formal Name
2-methyl-6S-(4-methylphenyl)-2-hepten-4-one
CAS Number
532-65-0
Synonyms
  • (S)-(+)-ar-Turmerone
Molecular Formula
C15H20O
Formula Weight
Purity
≥95%
A solution in ethanol
Ethanol: Miscible
λmax
220, 240 nm
SMILES
CC1=CC=C([C@@H](C)CC(/C=C(C)/C)=O)C=C1
InChi Code
InChI=1S/C15H20O/c1-11(2)9-15(16)10-13(4)14-7-5-12(3)6-8-14/h5-9,13H,10H2,1-4H3/t13-/m0/s1
InChi Key
NAAJVHHFAXWBOK-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (+)-ar-Turmerone is an aromatic compound from the rhizomes of C. longa, a perennial plant of the ginger family, Zingiberaceae, commonly used in traditional Asian medicines.1 It is also a major constituent of essential oil of turmeric, which is known for its antioxidant, anti-inflammatory, and anti-nociceptive properties.2 Two structurally and physiologically distinct forms of turmerone have been isolated from C. longa, (+)-ar-Turmerone and α-turmerone.1 (+)-ar-Turmerone stimulates the proliferation of peripheral blood mononuclear cells and increases the production of TNF-α, IL-2, and IFN-γ.1 It also promotes the maturation of dendritic cells and induces the proliferation of neural stem cells both in vitro and in vivo.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yue, G.G.L., Chan, B.C.L., Hon, P.M., et alEvaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem. Toxicol. 48(8-9), 2011-2020 (2010).

    2. Liju, V.B., Jeena, K., and Kuttan, R. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J. Pharmacol. 43(5), 526-531 (2011).

    3. Yonggang, T., Yiming, M., Heying, Z., et alMaturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum. Vaccin. Immunother. 8(10), 1416-1424 (2012).

    4. Hucklenbrioch, J., Klein, R., Neumaier, B., et alAromatic-turmerone induces neural stem cell proliferation in vitro and in vivo. Stem Cell Res.Ther. 5(4), 100 (2014).