A plant alkaloid with vasodilator effects
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Vincamine

Item No. 11763

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,14β,16α)-14,15-dihydro-14-hydroxy-eburnamenine-14-carboxylic acid, methyl ester
CAS Number
1617-90-9
Synonyms
  • Angiopac
  • Devincan
  • Equipur
  • Minorin
  • NSC 91998
  • Novicet
  • Oxybral
  • Perval
  • Sostenil
  • Tripervan
Molecular Formula
C21H26N2O3
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/ml
λmax
227, 281 nm
SMILES
CC[C@]1(CCC2)C[C@@](C(OC)=O)(O)N3C4=CC=CC=C4C5=C3[C@@]1([H])N2CC5
InChi Code
InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1
InChi Key
RXPRRQLKFXBCSJ-GIVPXCGWSA-N
Origin
Plant/Catharanthus roseus, Plant/Vinca minor
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $54

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    1 g

    $91

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    5 g

    $341

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    Product Description

    Vincamine is an indole alkaloid found in the leaves of V. minor and C. roseus that is used as a peripheral vasodilator to increase blood flow to the brain.1 Vincamine contracts excised human cerebrovascular smooth muscle in vitro with an EC50 value of 30 μM and has been explored as a pharmacotherapy to treat cerebral metabolic and vascular diseases.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lim, C.C., and James, I.M. The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers. Br. J. Clin. Pharmacol. 9(1), 100-101 (1980).

    2. Young, A.R., Bouloy, M., Boussard, J.F., et al. Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels. J. Cereb. Blood Flow Metab. 1(1), 117-128 (1981).

    3. Nowicki, J.P., MacKenzie, E.T., and Spinnewyn, B. Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondria. J. Cereb. Blood Flow Metab. 2(1), 33-40 (1982).