A methionine analog for click chemistry
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Product Categories

Product Type

Biochemicals

Application

Click Chemistry

L-Homopropargyl Glycine (hydrochloride)

Item No. 11785

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2-amino-5-hexynoic acid, monohydrochloride
CAS Number
942518-19-6
Synonyms
  • Click Tag™ L-Homopropargyl Glycine
  • HPG
Molecular Formula
C6H9NO2 • HCl
Formula Weight
163.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
C#CCC[C@H](N)C(O)=O.Cl
InChi Code
InChI=1S/C6H9NO2.ClH/c1-2-3-4-5(7)6(8)9;/h1,5H,3-4,7H2,(H,8,9);1H/t5-;/m0./s1
InChi Key
XGBWOGGSQVMSRX-JEDNCBNOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $55

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    50 mg

    $203

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    100 mg

    $268

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    Product Description

    L-Homopropargyl glycine is a reactive methionine analog that contains an alkyne moiety. It is readily inserted into newly-synthesized proteins in place of methionine.1,2,3 L-Homopropargyl glycine can then be labeled or captured through click chemistry.2,4 This approach represents a fast, sensitive, and non-radioactive alternative to [35S]-methionine for the detection of nascent protein synthesis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beatty, K.E., and Tirrell, D.A. Two-color labeling of temporally defined protein populations in mammalian cells. Bioorg. Med. Chem. Lett. 18(22), 5995-5999 (2008).

    2. Ngo, J.T., and Tirrell, D.A. Non-canonical amino acids in the interrogation of cellular protein synthesis. Acc. Chem. Res. 44(9), 677-685 (2011).

    3. Landgraf, P., Antileo, E.R., Schuman, E.M., et al. BONCAT: Metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes. Site-specific protein labeling 1266, 199-215 (2015).

    4. Dieterich, D.C., Hodas, J.J.L., Gouzer, G., et al. In situ visualization and dynamics of newly synthesized proteins in rat hippocampal neurons. Nat. Neurosci. 13(7), 897-905 (2010).