An inhibitor of MAGL
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JW 642

Item No. 11789

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
CAS Number
1416133-89-5
Molecular Formula
C21H20F6N2O3
Formula Weight
462.4
Purity
≥98%
Formulation (Request formulation change)
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 5 mg/mlEthanol: 13 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1
InChi Code
InChI=1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2
InChi Key
AVSCNEOUWSVZEY-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $55

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    10 mg

    $79

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    Product Description

    JW 642 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 3.7, 7.6, and 14 nM for the human, mouse, and rat enzymes, respectively).1 It is selective for MAGL over fatty acid amide hydrolase (FAAH; IC50s = 20.6, 31, and 14 µM for the human, mouse, and rat enzymes, respectively), as well as α/β-hydrolase domain-containing protein 6 (ABHD6; IC50s = 107 and 50 nM for the mouse and rat enzymes, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, J.W., Niphakis, M.J., Lum, K.M., et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol. 19(5), 579-588 (2012).