An inhibitor of MAGL
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

JW 642

Item No. 11789

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
CAS Number
1416133-89-5
Molecular Formula
C21H20F6N2O3
Formula Weight
462.4
Purity
≥98%
Formulation
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 11 mg/mlDMSO: 5 mg/mlEthanol: 13 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
SMILES
O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1
InChi Code
InChI=1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2
InChi Key
AVSCNEOUWSVZEY-UHFFFAOYSA-N
License
Sold under license from The Scripps Research Institute.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $55

    Add

    10 mg

    $79

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    JW 642 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 3.7, 7.6, and 14 nM for the human, mouse, and rat enzymes, respectively).1 It is selective for MAGL over fatty acid amide hydrolase (FAAH; IC50s = 20.6, 31, and 14 µM for the human, mouse, and rat enzymes, respectively), as well as α/β-hydrolase domain-containing protein 6 (ABHD6; IC50s = 107 and 50 nM for the mouse and rat enzymes, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, J.W., Niphakis, M.J., Lum, K.M., et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol. 19(5), 579-588 (2012).