An inhibitor of MAGL
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JW 618

Item No. 11790

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-N-[[3-(4-pyridinyl)phenyl]methyl]-, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester-carbamic acid
CAS Number
1416133-88-4
Molecular Formula
C17H14F6N2O2
Formula Weight
392.3
Purity
≥98%
Formulation
A 50 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 5 mg/mlEthanol: 16 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
256 nm
SMILES
O=C(OC(C(F)(F)F)C(F)(F)F)N(C)CC1=CC(C2=CC=NC=C2)=CC=C1
InChi Code
InChI=1S/C17H14F6N2O2/c1-25(15(26)27-14(16(18,19)20)17(21,22)23)10-11-3-2-4-13(9-11)12-5-7-24-8-6-12/h2-9,14H,10H2,1H3
InChi Key
RBZKWMMBPOHSDF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $119

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    25 mg

    $279

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    50 mg

    $493

    Add
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    Product Description

    JW 618 is an inhibitor of MAGL that displays IC50 values of 123, 385, and 6.9 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively.1 JW 618 is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s all > 50 µM for mouse, rat, and human brain membranes).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chang, J.W., Niphakis, M.J., Lum, K.M., et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol. 19(5), 579-588 (2012).