A neuroprotective natural product
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Withanolide A

Item No. 11797

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6α,7α-epoxy-5α,20,22R-trihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
CAS Number
32911-62-9
Synonyms
  • Withaniol
  • WL-A
Molecular Formula
C28H38O6
Formula Weight
470.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 0.1 mg/mlMethanol: .5 mg/ml
λmax
226 nm
SMILES
O=C(O1)C(C)=C(C)C[C@]1([H])[C@@](O)(C)[C@H]2CC[C@@]3([H])[C@]4([H])[C@H]5[C@H](O5)[C@@]([C@@]6(C)[C@@]4([H])CC[C@@]32C)(O)CC=CC6=O
InChi Code
InChI=1S/C28H38O6/c1-14-13-20(33-24(30)15(14)2)27(5,31)18-9-8-16-21-17(10-12-25(16,18)3)26(4)19(29)7-6-11-28(26,32)23-22(21)34-23/h6-7,16-18,20-23,31-32H,8-13H2,1-5H3/t16-,17-,18-,20+,21-,22-,23-,25-,26-,27+,28-/m0/s1
InChi Key
DXWHOKCXBGLTMQ-SFQAJKIESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $54

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    1 mg

    $102

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    5 mg

    $341

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    10 mg

    $575

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    Product Description

    Withanolide A is a natural product isolated from the medicinal plant W. somnifera that has antioxidant and neuroprotective activity.1 It helps to promote neurite outgrowth at 1 µM in cultured neurons and in rodents injected with Aβ(25-35), and also recovers Aβ(25-35)-induced memory deficit in mice (10 µmol/kg/day).2,3 Withanolide A reverses hypoxia-mediated neurodegeneration by restoring hypoxia-induced glutathione depletion in the hippocampus of mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kurapati, K.R.V., Samikkannu, T., Atluri, V.S.R., et al. β-Amyloid1-42, HIV-1Bα-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A. PLoS One 9(11), 1-23 (2014).

    2. Zhao, J., Nakamura, N., Hattori, M., et al. Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities. Chem. Pharm. Bull. (Tokyo) 50(6), 760-765 (2002).

    3. Kuboyama, T., Tohda, C., and Komatsu, K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br. J. Pharmacol. 144(7), 961-971 (2005).

    4. Baitharu, I., Jain, V., Deep, S.N., et al. Withanolide A prevents neurodegeneration by modulating hippocampal glutathione biosynthesis during hypoxia. PLoS One 9(10), 1-17 (2014).