(-)-Epigallocatechin (CAS 970-74-1) | Cayman Chemical
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(−)-Epigallocatechin

Item № 11809
CAS № 970-74-1
Purity ≥98%
product image
                (CAS 970-74-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $25.00 0.00
     5 mg $81.00 0.00
     10 mg $125.00 0.00
     25 mg $281.00 0.00

Pricing updated 2019-01-15. Prices are subject to change without notice.

Description
Synonyms
  • (−)-EGC
  • epi-Gallocatechin
  • NSC 674039

(−)-Epigallocatechin ((−)-EGC) is a major green tea polyphenol with antioxidant, anti-inflammatory, and anticancer activities. It has been shown to scavenge DPPH radicals with an EC50 value of 0.01 mM and to prevent the growth of several different AML cell lines at micromolar concentrations.1,2,3 Furthermore, at 30 µM (−)-EGC can inhibit heregulin-β1-induced migration/invasion of MCF-7 human breast cancer cells.4

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Technical Information
Formal Name
(2R,3R)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
CAS Number
970-74-1
Synonyms
  • (−)-EGC
  • epi-Gallocatechin
  • NSC 674039
Molecular Formula
C15H14O7
Formula Weight
306.3
Purity
≥98%
Formulation
A crystalline solid
λmax
209 nm
SMILES
OC1=CC2=C(C[C@@H](O)[C@@H](C3=CC(O)=C(O)C(O)=C3)O2)C(O)=C1
InChI Code
InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
InChI Key
XMOCLSLCDHWDHP-IUODEOHRSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Xu, J.Z., Yeung, S.Y.V., Chang, Q., et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers British Journal of Nutrition 91(6), 873-881 (2004).

2. Kadome, Y., and Fujisawa, S. Radical-scavenging activity of dietary phytophenols in combination with co-antioxidants using the induction period method Molecules 16, 10457-10470 (2011).

3. Ly, B.T.K., Chi, H.T., Yamagishi, M., et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells PLoS One 8(6), 1-9 (2013).

4. Kushima, Y., Iida, K., Nagaoka, Y., et al. Inhibitory effect of (−)-epigallocatechin and (−)-epigallocatechin gallate against heregulin β1-induced migration/invasion of the MCF-7 breast carcinoma cell line Biological and Pharmaceutical Bullentin 32(5), 899-904 (2009).

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