A green tea polyphenol
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(−)-Epigallocatechin

Item No. 11809

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R,3R)-3,4-dihydro-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3,5,7-triol
CAS Number
970-74-1
Synonyms
  • (−)-EGC
  • epi-Gallocatechin
  • NSC 674039
Molecular Formula
C15H14O7
Formula Weight
306.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
209 nm
SMILES
OC1=CC2=C(C[C@@H](O)[C@@H](C3=CC(O)=C(O)C(O)=C3)O2)C(O)=C1
InChi Code
InChI=1S/C15H14O7/c16-7-3-9(17)8-5-12(20)15(22-13(8)4-7)6-1-10(18)14(21)11(19)2-6/h1-4,12,15-21H,5H2/t12-,15-/m1/s1
InChi Key
XMOCLSLCDHWDHP-IUODEOHRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    (−)-Epigallocatechin ((−)-EGC) is a major green tea polyphenol with antioxidant, anti-inflammatory, and anticancer activities. It has been shown to scavenge DPPH radicals with an EC50 value of 0.01 mM and to prevent the growth of several different AML cell lines at micromolar concentrations.1,2,3 Furthermore, at 30 µM (−)-EGC can inhibit heregulin-β1-induced migration/invasion of MCF-7 human breast cancer cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, J.Z., Yeung, S.Y.V., Chang, Q., et al. Comparison of antioxidant activity and bioavailability of tea epicatechins with their epimers. Br. J. Nutr. 91(6), 873-881 (2004).

    2. Kadome, Y., and Fujisawa, S. Radical-scavenging activity of dietary phytophenols in combination with co-antioxidants using the induction period method. Molecules 16(12), 10457-10470 (2011).

    3. Ly, B.T.K., Chi, H.T., Yamagishi, M., et al. Inhibition of FLT3 expression by green tea catechins in FLT3 mutated-AML cells. PLoS One 8(6), e66378 (2013).

    4. Kushima, Y., Iida, K., Nagaoka, Y., et al. Inhibitory effect of (‒)-epigallocatechin and (−)-epigallocatechin gallate against heregulin β1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol. Pharm. Bull. 32(5), 899-904 (2009).