An antiparasitic compound
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Labeled Version(s)
28517Artemether-d3
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Artemether

Item No. 11815

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
CAS Number
71963-77-4
Synonyms
  • (+)-Artemether
  • SM-224
Molecular Formula
C16H26O5
Formula Weight
298.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 10 mg/mlEthanol: 16 mg/ml
SMILES
CO[C@H]1O[C@@]2([H])[C@]3(OO4)[C@](CC[C@@H](C)[C@]3([H])CC[C@]4(C)O2)([H])[C@H]1C
InChi Code
InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChi Key
SXYIRMFQILZOAM-HVNFFKDJSA-N
Origin
Plant/Artemisia annua
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Artemether is an antiparasitic compound and a derivative of artemisinin (Item No. 11816).1 It induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively).2 Artemether reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice with 50% curative dose (CD50) values of 7.1 and 55 mg/kg, respectively.3 It also reduces the worm burden of S. mansoni trematodes in mice when used at doses ranging from 200 to 500 mg/kg.1 Formulations containing artemether have been used in the treatment of malaria.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiao, S.H., and Catto, B.A. In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni. Antimicrob. Agents Chemother. 33(9), 1557-1562 (1989).

    2. Pillai, D.R., Lau, R., Khairnar, K., et al. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Malar. J. 11, 131 (2012).

    3. Shmuklarsky, M.J., Klayman, D.L., Milhous, W.K., et al. Comparison of β-artemether and β-arteether against malaria parasites in vitro and in vivo. Am. J. Trop. Med. Hyg. 48(3), 377-384 (1993).