A natural polyphenol
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Corilagin

Item No. 11832

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
cyclic 3,6-[(1R)-4,4',5,5',6,6'-hexahydroxy[1,1'-biphenyl]-2,2'-dicarboxylate] 1-(3,4,5-trihydroxybenzoate)-β-D-glucopyranose
CAS Number
23094-69-1
Molecular Formula
C27H22O18
Formula Weight
634.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
220, 268 nm
SMILES
O=C(C1=CC(O)=C(O)C(O)=C1C2=C(O)C(O)=C(O)C=C2C3=O)OCC4C(O)C(O3)C(O)C(OC(C5=CC(O)=C(O)C(O)=C5)=O)O4
InChi Code
InChI=1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2
InChi Key
TUSDEZXZIZRFGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $120

    Add

    10 mg

    $186

    Add

    25 mg

    $294

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Corilagin is a polyphenol and hydrolyzable tannin that can be isolated from a variety of plants.1,2 It inhibits squalene epoxidase (IC50 = 4.0 µM), a key enzyme in cholesterol synthesis.1 Corilagin also has various anti-inflammatory and anti-cancer effects.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abe, I., Kashiwagi, Y., Noguchi, H., et al. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. J. Nat. Prod. 64(8), 1010-1014 (2001).

    2. Gambari, R., Borgatti, M., Lampronti, I., et al. Corilagin is a potent inhibitor of NF-kappaB activity and downregulates TNF-alpha induced expression of IL-8 gene in cystic fibrosis IB3-1 cells. Int. Immunopharmacol. 13(3), 308-315 (2012).

    3. Xiao, H.T., Lin, C.Y., Ho, D.H.H., et al. Inhibitory effect of the gallotannin corilagin on dextran sulfate sodium-induced murine ulcerative colitis. J. Nat. Prod. 76(11), 2120-2125 (2013).

    4. Jia, L., Jin, H., Zhou, J., et al. A potential anti-tumor herbal medicine, corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways. BMC Complement. Altern. Med. 13, 33 (2013).

    5. Gambari, R., Hau, D.K.P., Wong, W.Y., et al. Sensitization of Hep3B hepatoma cells to cisplatin and doxorubicin by corilagin. Phytother. Res. 28(5), 781-783 (2014).