A natural antioxidant with diverse actions
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Active Metabolite(s)
1184518β-Glycyrrhetinic Acid
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Glycyrrhizic Acid (ammonium salt)

Item No. 11847

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
20β-carboxy-11-oxo-30-norolean-12-en-3β-yl 2-O-β-D-glucopyranuronosyl-α-D-glucopyranosiduronic acid, monoammonium salt
CAS Number
53956-04-0
Synonyms
  • Ammonium Glycyrrhizinate
  • Glycyrrhizin
  • Glycyrrhizinate
  • NSC 2800
  • NSC 35348
Molecular Formula
C42H62O16 • NH3
Formula Weight
840.0
Purity
≥80%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mLDMSO: 20 mg/mLPBS (pH 7.2): 1 mg/mL
λmax
249 nm
SMILES
O=C1[C@@]2([H])[C@](CC[C@]3([H])[C@]2(C)CC[C@H](O[C@@]4([H])O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O[C@@]5([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O5)C3(C)C)(C)[C@]6(C)CC[C@@]7(C)CC[C@@](C(O)=O)(C)C[C@@]7([H])C6=C1.N
InChi Code
InChI=1S/C42H62O16.H3N/c1-37(2)21-8-11-42(7)31(20(43)16-18-19-17-39(4,36(53)54)13-12-38(19,3)14-15-41(18,42)6)40(21,5)10-9-22(37)55-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50;/h16,19,21-31,34-35,44-48H,8-15,17H2,1-7
InChi Key
ILRKKHJEINIICQ-OOFFSTKBSA-N
Origin
Plant/Glycyrrhiza glabra
Shipping & Storage Information
Storage
Room temperature
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

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    Product Description

    Glycyrrhizic acid is a natural triterpenoid saponin that can be isolated from the root of licorice. It is an agonist of the human sweet taste receptor and is used as a flavorant.1 Glycyrrhizic acid has diverse cellular effects at low doses, including antioxidant, anti-inflammatory, antimicrobial, and antiviral actions.2,3,4 Presumably through its role as an antioxidant, glycyrrhizic acid alters signaling through a variety of signaling pathways, impacting pathologies such as metabolic syndrome, fibrosis, and ultraviolet-B-induced skin damage in cellular and animal models.5,6,7

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtsu, Y., Nakagawa, Y., Nagasawa, M., et al. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells. Mol. Cell. Endocrinol. 394(1-2), 70-79 (2014).

    2. Ming, L.J., and Yin, A.C. Therapeutic effects of glycyrrhizic acid. Nat. Prod. Commun. 8(3), 415-418 (2013).

    3. Wang, L., Yang, R., Yuan, B., et al. The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb. Acta Pharm. Sin. B 5(4), 310-315 (2015).

    4. Lee, K.J., Oh, Y.C., Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evid. Based Complement. Alternat. Med. 165457 (2015).

    5. Afnan, Q., Kaiser, P.J., Rafig, R.A., et al. Glycyrrhizic acid prevents ultraviolet-B-induced photodamage: a role for mitogen-activated protein kinases, nuclear factor kappa B and mitochondrial apoptotic pathway. Exp. Dermatol. 25(6), 440-446 (2016).

    6. Cheng, H.S., Kong, J.M., Ng, A.X., et al. Novel inhibitory effects of glycyrrhizic acid on the accumulation of advanced glycation end product and its receptor expression. Nat. Prod. Bioprospect. 4(6), 325-333 (2014).

    7. Zhou, Y., Tong, X., Ren, S., et al. Synergistic anti-liver fibrosis actions of total astragalus saponins and glycyrrhizic acid via TGF-β1/Smads signaling pathway modulation. J. Ethnopharmacol. 190, 83-90 (2016).

    Product Citations

    Tagi, H., Qiu, C., Zeng, Y., et al. Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis. Theranostics 15(1), 5087-5105 (2025).