For the immunochemical analysis of Prostaglandin Transporter (C-Term)
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Prostaglandin Transporter (C-Term) Polyclonal Antibody

Item No. 11860

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • OATP2A1
  • PGT
  • SLCO2A1
  • Solute carrier organic anion transporter family member 2A1
Immunogen
A synthetic peptide from the C-terminal region of human PGT
Formulation (Request formulation change)
500 µl of peptide affinity purified polyclonal antibody
Storage Buffer
PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide
Host
Rabbit
Applications
WB
Species Reactivity
(+) Human(+) Cow(+) Sheep; other species not tested
UniProt Accession №
Q92959
Origin
Animal/Rabbit
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 ea (500 µl)

    $347

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    Product Description

    Prostaglandins (PGs) are signaling molecules that modulate physiological or pathologic functions such as platelet aggregation, vascular tone, gastric cytoprotection, uterine contraction, inflammation, cancer and Alzheimer’s disease.1,2,3,4,5,6 PG transporter (PGT) is generally expressed in endothelial and epithelial cells. Transport of extracellular PGs into cells occurs via a specific PGT, allowing PG oxidation by 15-hydroxy PG dehydrogenase or binding with their respective receptor(s).7,8,9 Cayman’s peptide-affinity purified PGT polyclonal antibody detects a 71 kDa band on WB. Loss of PGT detection may occur due to cell membrane aggregation during exposure of some samples to high temperature processing.10 Therefore treatment of the protein sample at 37°C for 15 minutes (water bath or heating block), and if desired, in parallel with another aliquot at 95°C is recommended prior to electrophoresis and blotting. When using the antibody for ICC or IF, cell permeabilization is necessary due to the intracellular location of the antibody binding site (C-terminal amino acids).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Samuelsson, B., Granström, E., Green, K., et al. Prostaglandins. Annu. Rev. Biochem. 44, 669-695 (1975).

    2. Holm, L., and Jägare, A. Role of prostaglandins in regulation of gastric mucosal blood flow and acid secretion. Am. J. Physiol. 263(4 Pt 1), G446-G451 (1992).

    3. Gobbetti, A., Zerani, M., Vannucci, F., et al. Prostaglandins and sex steroids from corpora leutea of pregnant mares. In vitro studies. Prostaglandins 48(4), 262-272 (1994).

    4. Harris, S.G., Padilla, J., Koumas, L., et al. Prostaglandins as modulators of immunity. Trends Immunol. 23(3), 144-150 (2002).

    5. Engblom, D., Ek, M., Saha, S., et al. Prostaglandins as inflammatory messengers across the blood-brain barrier. J. Mol. Med. (Berl.) 80(1), 5-15 (2002).

    6. Tilley, S.L., Coffman, T.M., and Koller, B.H. Mixed messages: Modulation of inflammation and immune responses by prostaglandins and thromboxanes. J. Clin. Invest. 108(1), 15-23 (2001).

    7. Kanai, N., Lu, R., Satriano, J.A., et al. Identification and characterization of a prostaglandin transporter. Science 268(5212), 866-869 (1995).

    8. Lu, R., Kanai, N., Bao, Y., et al. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA (hPGT). J. Clin. Invest. 98(5), 1142-1149 (1996).

    9. Subbaramaiah, K., Hudis, C.A., and Dannenberg, A.J. The prostaglandin transporter regulates adipogenesis and Aromatase transcription. Cancer Prev. Res. (Phila.) 4(2), 194-206 (2011).

    10. Schägger, H. Tricine-SDS-PAGE. Nat. Protoc. 1(1), 16-22 (2006).