An Analytical Reference Standard
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Alternative(s)
115554-MTA
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4-MTA (hydrochloride)

Item No. 11862

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-Methylthioamphetamine
  • P 1882
Technical Information
Formal Name
α-methyl-4-(methylthio)-benzeneethanamine, monohydrochloride
CAS Number
94784-92-6
Molecular Formula
C10H15NS • HCl
Formula Weight
217.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 11 mg/mlMethanol: 1 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
258 nm
SMILES
NC(C)CC1=CC=C(SC)C=C1.Cl
InChi Code
InChI=1S/C10H15NS.ClH/c1-8(11)7-9-3-5-10(12-2)6-4-9;/h3-6,8H,7,11H2,1-2H3;1H
InChi Key
DGCZWGSFSFNXNS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-MTA (Item No. 11862), is a selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits monoamine oxidase A.1,2,3 The detection of this designer drug in serum and urine has been described, as has its metabolism.3,4,5,6 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huang, X., Marona-Lewicka, D., and Nichols, D.E. p-Methylthioamphetamine is a potent new non-neurotoxic serotonin-releasing agent. Eur. J. Pharmacol. 229(1), 31-38 (1992).

    2. Gobbi, M., Moia, M., Pirona, L., et al. p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. J. Neurochem. 82(6), 1435-1443 (2002).

    3. Staack, R.F., and Maurer, H.H. Metabolism of designer drugs of abuse. Curr. Drug Metab. 6(3), 259-274 (2005).

    4. Wohlfarth, A., Weinmann, W., and Dresen, S. LC-MS/MS screening method for designer amphetamines, tryptamines, and piperazines in serum. Anal. Bioanal. Chem. 396(7), 2403-2414 (2010).

    5. Kerrigan, S., Banuelos, S., Perrella, L., et al. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. J. Anal. Toxicol. 35(7), 459-469 (2011).

    6. Ewald, A.H., Peters, F.T., Weise, M., et al. Studies on the metabolism and toxicological detection of the designer drug 4-methylthioamphetamine (4-MTA) in human urine using gas chromatography-mass spectrometry. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 824(1-2), 123-131 (2005).