A lipophilic antioxidant
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Ferulic Acid ethyl ester

Item No. 11880

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid, ethyl ester
CAS Number
4046-02-0
Synonyms
  • BBR 3222
  • NSC 14879
Molecular Formula
C12H14O4
Formula Weight
222.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 11 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
218, 236, 326 nm
SMILES
COC1=C(O)C=CC(/C=C/C(OCC)=O)=C1
InChi Code
InChI=1S/C12H14O4/c1-3-16-12(14)7-5-9-4-6-10(13)11(8-9)15-2/h4-8,13H,3H2,1-2H3/b7-5+
InChi Key
ATJVZXXHKSYELS-FNORWQNLSA-N
Origin
Plant/Ferula communis
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Product Description

    Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes.1 Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging).2 However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide.3,4 Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sultana, R. Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders. Biochim. Biophys. Acta 1822(5), 748-752 (2012).

    2. Garrido, J., Gaspar, A., Garrido, E.M., et al. Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress. Biochimie 94(4), 961-967 (2012).

    3. Sultana, R., Ravagna, A., Mohmmad-Abdul, H., et al. Ferulic acid ethyl ester protects neurons against amyloid β-peptide(1-42)-induced oxidative stress and neurotoxicity: Relationship to antioxidant activity. J. Neurochem. 92(4), 749-758 (2005).

    4. Joshi, G., Perluigi, M., Sultana, R., et al. In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane) dihydrochloride (AAPH) or Fe2+/H2O2: Insight into mechanisms of neuroprotection and relevance to oxidative stress-related neurodegenerative disorders. Neurochem. Int. 48(4), 318-327 (2006).

    5. Di Domenico, F., Perluigi, M., Foppoli, C., et al. Protective effect of ferulic acid ethyl ester against oxidative stress mediated by UVB irradiation in human epidermal melanocytes. Free Radic. Res. 43(4), 365-375 (2009).