6-Shogaol

6-Shogaol is a minor, bioactive component of ginger (Zingiber officinale Roscoe) with anti-inflammatory and anticancer properties. It is present in fresh ginger at low levels, but quantities of 6-shogaol are significantly increased in dried ginger. 6-Shogaol induces apoptosis in cancer cells through the production of reactive oxygen species and the activation of caspase, impairs tubulin polymerization, downregulates NF-κB signaling, inhibits the expression of inflammatory mediators, and suppresses Toll-like receptor signaling.¹ 6-Shogaol-rich extracts have been shown to enhance antioxidant defense mechanisms by inducing Nrf2/ARE-mediated gene expression in cell and animal models.² It can also activate both TRPV1 and TRPA1 channels (EC₅₀s = 0.32 and 16 µM, respectively).³

WARNING This product is not for human or veterinary use.

1. Ling, H., Yang, H., Tan, S.H., et al. 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. Br. J. Pharmacol. 161(8), 1763-1777 (2010).

2. Bak, M.J., Ok, S., Jun, M., et al. 6-Shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. Molecules 17, 8037-8055 (2012).

3. Morera, E., De Petrocellis, L., Morera, L., et al. Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorg. Med. Chem. Lett. 22(4), 1674-1677 (2012).

Pázmándi, K., Ágics, B., Szöllősi, A.G., et al. Ginger-derived bioactive compounds attenuate the Toll-like receptor mediated responses of human dendritic cells. Eur. J. Pharmacol. 967, 176399 (2024).

Moaddel, R., Rossi, M., Rodriguez, S., et al. Identification of gingerenone A as a novel senolytic compound. PLoS One 17(3), e0266135 (2022).