An NSAID and a prodrug form of salicylic acid
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Salsalate

Item No. 11911

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-2-carboxyphenyl ester-benzoic acid
CAS Number
552-94-3
Synonyms
  • NSC 49171
  • Nobacid
Molecular Formula
C14H10O5
Formula Weight
258.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 5 mg/mlEthanol: 3 mg/ml
λmax
207, 234, 308 nm
SMILES
OC1=CC=CC=C1C(OC2=C(C(O)=O)C=CC=C2)=O
InChi Code
InChI=1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
InChi Key
WVYADZUPLLSGPU-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $49

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    50 g

    $93

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    100 g

    $171

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    Product Description

    Salsalate is a non-steroidal anti-inflammatory drug (NSAID) and prodrug form of salicylic acid.1 It is converted to salicylic acid by hydrolysis. It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in isolated human whole blood stimulated with LPS (IC50 = 39.9 µM).2 Salsalate (1,000 mg/kg) inhibits weight gain and decreases fasting plasma glucose and insulin levels, as well as decreases plasma cholesterol and triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a high-fat high-cholesterol diet.3 Formulations containing salsalate have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shah, K., Gupta, J.K., Chauhan, N.S., et al. Prodrugs of NSAIDs: A Review. Open Med. Chem. J. (2017).

    2. Cryer, B., and Feldman, M. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of widely used nonsteroidal anti-inflammatory drugs. Am. J. Med. 104(5), 413-421 (1998).

    3. Liang, W., Verschuren, L., Mulder, P., et al. Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes. Br. J. Pharmacol. 172(22), 5293-5305 (2015).