A reversible channel blocker of TRPA1
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AP-18

Item No. 11912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-chlorophenyl)-3-methyl-3-buten-2-one, oxime
CAS Number
55224-94-7
Molecular Formula
C11H12ClNO
Formula Weight
209.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 20 mg/ml
λmax
216, 274 nm
SMILES
ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1
InChi Code
InChI=1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+
InChi Key
MHTJEUOFLVQMCL-NJHPPEEMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $63

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    10 mg

    $94

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    25 mg

    $213

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    50 mg

    $363

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    Product Description

    AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 µM, human and mouse, respectively).1,2 It has minimal effect on TRPV1-4 or TRPM8.1 AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.1,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Petrus, M., Peier, A.M., Bandell, M., et al. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol. Pain 3, 40 (2007).

    2. Fanger, C.M., del Camino, D., and Moran, M.M. TRPA1 as an analgesic target. Open Drug Discov.J. 2, 64-70 (2010).

    3. Chen, J., Kim, D., Bianchi, B.R., et al. Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol. Pain 5, 3 (2009).

    4. Taylor-Clark, T.E., Ghatta, S., Bettner, W., et al. Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol. Pharmacol. 75(4), 820-829 (2009).