An α2-AR agonist
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B-HT 933 (hydrochloride)

Item No. 11941

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine, dihydrochloride
CAS Number
36067-72-8
Synonyms
  • Azepexole
  • Oxazoloazepin
Molecular Formula
C9H15N3O • 2HCl
Formula Weight
254.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
220 nm
SMILES
CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl
InChi Code
InChI=1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H
InChi Key
HBLPYIOKPJVFQW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    10 mg

    $219

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    25 mg

    $502

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    Product Description

    B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins.1 It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum.2 B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine (Item No. 19869).3 B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally.4 It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ruffolo, R.R., Jr., and Zeid, R.L. Relationship between alpha 2-adrenoceptor occupancy and response for B-HT 933 in canine saphenous vein. Eur. J. Pharmacol. 111(2), 267-271 (1985).

    2. Vargas, M.L., and Brugger, A.J. Mechanism of action of B-HT 933 (azepexole) in rat vas deferens and guinea-pig ileum. Eur. J. Pharmacol. 119(3), 137-141 (1985).

    3. Anden, N.-E. Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT920 and B-HT933, respectively. Naunyn-Schmiedebergs Arch. Pharmacol. 321, 100-104 (1982).

    4. Santa-Maria, I., Hernandez, F., Del Rio, J., et al. Tramiprostate, a drug of potential interest for the treatment of Alzheimer’s disease, promotes an abnormal aggregation of tau. Mol. Neurodegener. 2, 17-29 (2007).

    5. Vargas, M.L., Bansinath, M., Turndorf, H., et al. Antinociceptive effects of azepexole (BHT 933) in mice. Pain 36(1), 117-123 (1989).