An α2D-adrenergic receptor agonist
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RWJ 52353 (hydrochloride)

Item No. 11942

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(6,7-dihydrobenzo[b]thien-4-yl)-1H-imidazole, monohydrochloride
CAS Number
245744-13-2
Molecular Formula
C11H10N2S • HCl
Formula Weight
238.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C1(SC=C2)=C2C(C3=CN=CN3)=CCC1.Cl
InChi Code
InChI=1S/C11H10N2S.ClH/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1;/h2,4-7H,1,3H2,(H,12,13);1H
InChi Key
LIHWQUZNTRDJFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $378

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    10 mg

    $702

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    Product Description

    RWJ 52353 is an agonist of α2D-adrenergic receptors (α2D-ARs; Kis = 1.5, 254, 621, and 443 nM for α2D-, α2A-, α2B-, and α1-ARs, respectively).1 It has antinociceptive properties in the mouse and rat abdominal irritation tests (ED50s = 11.6 and 15.1 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, T.M., Jetter, M.C., McDonnell, M.E., et al. α2 Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J. Med. Chem. 43(7), 1423-1426 (2000).