An α2D-adrenergic receptor agonist
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

RWJ 52353 (hydrochloride)

Item No. 11942

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(6,7-dihydrobenzo[b]thien-4-yl)-1H-imidazole, monohydrochloride
CAS Number
245744-13-2
Molecular Formula
C11H10N2S • HCl
Formula Weight
238.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C1(SC=C2)=C2C(C3=CN=CN3)=CCC1.Cl
InChi Code
InChI=1S/C11H10N2S.ClH/c1-2-8(10-6-12-7-13-10)9-4-5-14-11(9)3-1;/h2,4-7H,1,3H2,(H,12,13);1H
InChi Key
LIHWQUZNTRDJFW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $103

    Add

    5 mg

    $378

    Add

    10 mg

    $702

    Add
    Product Description

    RWJ 52353 is an agonist of α2D-adrenergic receptors (α2D-ARs; Kis = 1.5, 254, 621, and 443 nM for α2D-, α2A-, α2B-, and α1-ARs, respectively).1 It has antinociceptive properties in the mouse and rat abdominal irritation tests (ED50s = 11.6 and 15.1 mg/kg, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ross, T.M., Jetter, M.C., McDonnell, M.E., et al. α2 Adrenoceptor agonists as potential analgesic agents. 2. Discovery of 4-(4-imidazo)-1,3-dimethyl-6,7-dihydro-thianaphthene as a high-affinity ligand for the α2D adrenergic receptor. J. Med. Chem. 43(7), 1423-1426 (2000).